Primary Cutaneous CD30 (-) Anaplastic Large Cell Lymphoma: A Rare Case Report

Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a rare type of non-Hodgkin’s lymphoma comprising approximately 0.9 9.0% of all cutaneous lymphomas. 75% of them are CD30 positive. PCALCL is characterized by the absence of systemic involvement, spontaneous regression and low recurrence rate especially in localized lesions. We present a 33-year-old male with a 1-year history of asymptomatic, well-defined, systemic involvement, diameter of 2 6 cm, irregularly-shaped erythematous plaques. Skin punch biopsy revealed dense infiltrates of non-epidermotropic, large, irregularly-shaped lymphocytes with hyperchromatic and pyknotic nuclei. Immunohistochemistry revealed that these atypical cells are CD3(+), CD5 dispersion (+), CD20(), CD79a(-), Ki-67(-), TdT(-), CD10(-), Bcl-6(-), CyclinD1(-), CD138 dispersion (+), MUM1(-), mitochondrial enzymes B(+), TIA-1(+++), CD4(++), CD8 dispersion(+), CD30(-), CD56(-). Clinical, histopathological and immunohistochemical findings are consistent with PC-ALCL. Regular VELP (Vincristine, Etoposide, L-Asaraginase, and Prednisone) chemotherapy resulted in total resolution of skin lesions. Because the clinical presentation of PC-ALCL can be variable, a high index of suspicion is necessary in patients presenting with chronic plaques and nodules unresponsive to topical or oral medications. *Corresponding author: Dr. Tao Wu, Department of Hematology, Lanzhou General Hospital, Lanzhou Command, 333 South Binhe Rd, Lanzhou, Gansu, 730050, China, Tel: +86-13919939297/ Fax: +86-931-2665486; E-mail: [email protected] Received Date: May 11, 2017 Accepted Date: October 23, 2017 Published Date: October 25, 2017